Article
Multiple homologous genes knockout (KO) by CRISPR/Cas9 system in rabbit.
Gene - 20 Mar 2018
Liu Huan, Sui Tingting, Liu Di, Liu Tingjun, Chen Mao, Deng Jichao, Xu Yuanyuan, Li Zhanjun
Abstract excerpt
The CRISPR/Cas9 system is a highly efficient and convenient genome editing tool, which has been widely used for single or multiple gene mutation in a variety of organisms. Disruption of multiple homologous genes, which have similar DNA sequences and gene function, is required for the study of the desired phenotype. In this study, to test whether the CRISPR/Cas9 system works on the mutation of multiple homologous...
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