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Article

Functionality and opposite roles of two interleukin 4 haplotypes in immune cells.

Genes and immunity - 1 Jan 2017

Anovazzi G, Medeiros M C, Pigossi S C, Finoti L S, Souza Moreira T M, Mayer M P A, Zanelli C F, Valentini S R, Rossa-Junior C, Scarel-Caminaga R M

Abstract excerpt

Cytokines expression can be influenced by polymorphisms in their respective coding genes. We associated the CTI/TTD haplotype (Hap-1) and TCI/CCI haplotype (Hap-2) in the IL4 gene formed by the -590, +33 and variable number of tandem repeat polymorphisms with the severity of chronic periodontitis in humans. The functionality of these IL4 haplotypes in the response of immune cells to phorbol 12-myristate...

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Identifiers

PMID: 28053321
DOI: 10.1038/gene.2016.47
PMCID: PMC5303765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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