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Article

Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Mar 2008

Wolf Alex M, Lyuksyutova Anna I, Fenstermaker Ali G, Shafer Beth, Lo Charles G, Zou Yimin

Abstract excerpt

Wnt proteins are conserved axon guidance cues that control growth cone navigation. However, the intracellular signaling mechanisms that mediate growth cone turning in response to Wnts are unknown. We previously showed that Wnt-Frizzled signaling directs spinal cord commissural axons to turn anteriorly after midline crossing through an attractive mechanism. Here we show that atypical protein kinase C (aPKC), is...

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Source

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Identifiers

PMID: 18367611
DOI: 10.1523/JNEUROSCI.0029-08.2008
PMCID: PMC6670589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance.PMID 18367611Read ↗

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