Article
Constitutively active myosin light chain kinase alters axon guidance decisions in Drosophila embryos.
Developmental biology - 15 Sept 2002
Kim You-Seung, Fritz Janice L, Seneviratne Ananda K, VanBerkum Mark F A
Abstract excerpt
Conventional myosin II activity provides the motile force for axon outgrowth, but to achieve directional movement during axon pathway formation, myosin activity should be regulated by the attractive and repulsive guidance cues that guide an axon to its target. Here, evidence for this regulation is obtained by using a constitutively active Myosin Light Chain Kinase (ctMLCK) to selectively elevate myosin II...
Topics
- Animals
- Animals, Genetically Modified
- Axons
- Base Sequence
- Chick Embryo
- Chickens
- DNA Primers
- Drosophila melanogaster
- Embryo, Nonmammalian
- Enzyme Activation
- Genotype