Article
Regulation of dendritic branching and spine maturation by semaphorin3A-Fyn signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Mar 2006
Morita Asa, Yamashita Naoya, Sasaki Yukio, Uchida Yutaka, Nakajima Oumi, Nakamura Fumio, Yagi Takeshi, Taniguchi Masahiko, Usui Hiroshi, Katoh-Semba Ritsuko, Takei Kohtaro, Goshima Yoshio
Abstract excerpt
A member of semaphorin family, semaphorin3A (Sema3A), acts as a chemorepellent or chemoattractant on a wide variety of axons and dendrites in the development of the nervous systems. We here show that Sema3A induces clustering of both postsynaptic density-95 (PSD-95) and presynaptic synapsin I in cultured cortical neurons without changing the density of spines or filopodia. Neuropilin-1 (NRP-1), a receptor for...
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