Article
CD44 regulates dendrite morphogenesis through Src tyrosine kinase-dependent positioning of the Golgi.
Journal of cell science - 1 Dec 2014
Skupien Anna, Konopka Anna, Trzaskoma PaweI, Labus Josephine, Gorlewicz Adam, Swiech Lukasz, Babraj Matylda, Dolezyczek Hubert, Figiel Izabela, Ponimaskin Evgeni, Wlodarczyk Jakub, Jaworski Jacek, Wilczynski Grzegorz M, Dzwonek Joanna
Abstract excerpt
The acquisition of proper dendrite morphology is a crucial aspect of neuronal development towards the formation of a functional network. The role of the extracellular matrix and its cellular receptors in this process has remained enigmatic. We report that the CD44 adhesion molecule, the main hyaluronan receptor, is localized in dendrites and plays a crucial inhibitory role in dendritic tree arborization in vitro...
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