Article
Experimental evolution and genome sequencing reveal variation in levels of clonal interference in large populations of bacteriophage phiX174.
BMC evolutionary biology - 17 Mar 2008
Pepin Kim M, Wichman Holly A
Abstract excerpt
BACKGROUND: In large asexual populations where beneficial mutations may co-occur and recombination is absent, the fate of beneficial mutations can be significantly affected by competition (i.e., clonal interference). Theoretical models predict that clonal interference (CI) can slow adaptation, alter the distribution of fixed beneficial mutations, and affect disease progression by impacting within-host evolution...
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