Article
Clonal interference and the periodic selection of new beneficial mutations in Escherichia coli.
Genetics - 1 Apr 2006
de Visser J Arjan G M, Rozen Daniel E
Abstract excerpt
The conventional model of adaptation in asexual populations implies sequential fixation of new beneficial mutations via rare selective sweeps that purge all variation and preserve the clonal genotype. However, in large populations multiple beneficial mutations may co-occur, causing competition among them, a phenomenon called "clonal interference." Clonal interference is thus expected to lead to longer fixation...
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