Article
Fitness effects of fixed beneficial mutations in microbial populations.
Current biology : CB - 25 Jun 2002
Rozen Daniel E, de Visser J Arjan G M, Gerrish Philip J
Abstract excerpt
Beneficial mutations are intuitively relevant to understanding adaptation, yet not all beneficial mutations are of consequence to the long-term evolutionary outcome of adaptation. Many beneficial mutations-mostly those of small effect-are lost due either to (1) genetic drift or to (2) competition...
Topics
- Adaptation, Physiological
- Directed Molecular Evolution
- Escherichia coli
- Genotype
- Models, Genetic
- Mutation