Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Historical Contingency Drives Compensatory Evolution and Rare Reversal of Phage Resistance.

Molecular biology and evolution - 1 Sept 2022

Debray Reena, De Luna Nina, Koskella Britt

Abstract excerpt

Bacteria and lytic viruses (phages) engage in highly dynamic coevolutionary interactions over time, yet we have little idea of how transient selection by phages might shape the future evolutionary trajectories of their host populations. To explore this question, we generated genetically diverse phage-resistant mutants of the bacterium Pseudomonas syringae. We subjected the panel of mutants to prolonged...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteria
Share to Bacteriophages
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 35994371
DOI: 10.1093/molbev/msac182
PMCID: PMC9447851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Historical Contingency Drives Compensatory Evolution and Rare Reversal of Phage Resistance.PMID 35994371Read ↗

Greater Phage Genotypic Diversity Constrains Arms-Race Coevolution.Semantic proximity Read ↗

Historical contingency in the evolution of antibiotic resistance after decades of relaxed selection.Semantic proximity Read ↗

Eco-evolutionary feedbacks shape the evolution of constitutive and inducible defencesSemantic proximity Read ↗

The effect of phage genetic diversity on bacterial resistance evolution.Semantic proximity Read ↗

Transient eco-evolutionary dynamics early in a phage epidemic have strong and lasting impact on the long-term evolution of bacterial defences.Semantic proximity Read ↗

The impact of phage and phage resistance on microbial community dynamicsSemantic proximity Read ↗

Rapid evolutionary turnover of mobile genetic elements drives bacterial resistance to phages.Semantic proximity Read ↗

Mutational heterogeneity: a key ingredient of bet-hedging and evolutionary divergence?: The broad spectrum of mutations and their flexible frequency in populations provides a source of risk avoidance and alternative evolutionary strategies.Semantic proximity Read ↗

The essential role of hypermutation in rapid adaptation to antibiotic stressSemantic proximity Read ↗

Phage-encoded contingency loci enable bet-hedging against host defence mechanisms.Semantic proximity Read ↗

Parasite diversity drives rapid host dynamics and evolution of resistance in a bacteria-phage system.Semantic proximity Read ↗

Coevolution with bacteriophages drives genome-wide host evolution and constrains the acquisition of abiotic-beneficial mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.