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Article

p16INK4a Translation Suppressed by miR-24

25 Mar 2008

Abstract excerpt

BACKGROUND: Expression of the tumor suppressor p16(INK4a) increases during aging and replicative senescence. METHODOLOGY/PRINCIPAL FINDINGS: Here, we report that the microRNA miR-24 suppresses p16 expression in human diploid fibroblasts and cervical carcinoma cells. Increased p16 expression with replicative senescence was associated with decreased levels of miR-24, a microRNA that was predicted to associate with...

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PMID: 18365017
DOI: 10.1371/journal.pone.0001864

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