Article
Perturbation of wild-type lamin A metabolism results in a progeroid phenotype.
Aging cell - 1 Jun 2008
Candelario Jose, Sudhakar Sivasubramaniam, Navarro Sonia, Reddy Sita, Comai Lucio
Abstract excerpt
Mutations in the lamin A/C gene cause the rare genetic disorder Hutchinson-Gilford progeria syndrome (HGPS). The prevalent mutation results in the production of a mutant lamin A protein with an internal 50 amino acid deletion which causes a cellular aging phenotype characterized by growth defects, limited replicative lifespan, and nuclear membrane abnormalities. However, the relevance of these findings to normal...
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