Colon cancer metastasis in mouse liver is not affected by hypercoagulability due to Factor V Leiden mutation.

Abstract excerpt

Clinical trials have shown life-prolonging effects of antithrombotics in cancer patients, but the molecular mechanisms remain unknown due to the multitude of their effects. We investigated in a mouse model whether one of the targets of antithrombotic therapy, fibrin deposition, stimulates tumour development. Fibrin may provide either protection of cancer cells in the circulation against mechanical stress and the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Colonic Neoplasms
• Share to Cytoplasm
• Share to Endothelial Cells