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Article

Genetic polymorphisms of the CASP8 gene promoter may not be associated with colorectal cancer in Han Chinese from southwest China.

PloS one - 1 Jan 2013

Xiao Mei-Sheng, Chang Le, Li Wen-Liang, Du Yong-Sheng, Pan Yue, Zhang Deng-Feng, Wen Yu, Luo Juan, Li Xiao-Yan, Yao Yong-Gang

Abstract excerpt

PURPOSE: Caspase 8 (CASP8) plays a critical role in the apoptotic pathway and aberrant regulation of this pathway causes many diseases including cancers. Genetic variants rs3834129 (CTTACT/-) and rs3769821 (T/C) in the promoter region of the CASP8 gene were documented to be associated with multiple solid cancers and non-Hodgkin's lymphoma (NHL), respectively, despite of some controversies. We aimed to discern...

Topics

Adult
Aged
Alleles
Asian People
Case-Control Studies
Caspase 8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Colorectal Neoplasms

Female

Gene Frequency

Genotype

Humans

Male

Middle Aged

Polymorphism, Genetic

Promoter Regions, Genetic

RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 23844036
DOI: 10.1371/journal.pone.0067577
PMCID: PMC3699664

Genes

CASP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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