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Article

The rexinoid, bexarotene, prevents the development of premalignant lesions in MMTV-erbB2 mice

25 Mar 2008

Abstract excerpt

Retinoids, vitamin A analogues that bind to retinoic acid receptor (RAR) or retinoid X receptor (RXR), play important roles in regulating cell proliferation, apoptosis, and differentiation. Recently, RXR-selective ligands, also referred to as rexinoids, have been investigated as potential chemopreventive agents for breast cancer. Our previous studies demonstrated that the rexinoid bexarotene significantly...

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PMID: 18362934
DOI: 10.1038/sj.bjc.6604320

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