Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2004

Dragnev Konstantin H, Pitha-Rowe Ian, Ma Yan, Petty W Jeffrey, Sekula David, Murphy Bryan, Rendi Mara, Suh Nanjoo, Desai Neil B, Sporn Michael B, Freemantle Sarah J, Dmitrovsky Ethan

Abstract excerpt

PURPOSE: There is a need to identify cancer chemoprevention mechanisms. We reported previously that all-trans-retinoic acid (RA) prevented carcinogenic transformation of BEAS-2B immortalized human bronchial epithelial cells by causing G(1) arrest, permitting repair of genomic DNA damage. G(1) arr...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticarcinogenic Agents
Share to Bronchi

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin D1

Share to Cyclin E

Share to G1 Phase

Share to Leupeptins

Share to Proteasome Inhibitors

Share to Retinoids

Source

Identifiers

PMID: 15073138
DOI: 10.1158/1078-0432.ccr-03-0271

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15073138-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy.PMID 15073138Read ↗

Uncovering residues that regulate cyclin D1 proteasomal degradation.Semantic proximity Read ↗

Cyclin degradation for cancer therapy and chemopreventionSemantic proximity Read ↗

Retinoids in biological control and cancerSemantic proximity Read ↗

β‐Cryptoxanthin suppresses the growth of immortalized human bronchial epithelial cells and non‐small‐cell lung cancer cells and up‐regulates retinoic acid receptor β expressionSemantic proximity Read ↗

Enterolactone Induces G1-phase Cell Cycle Arrest in Nonsmall Cell Lung Cancer Cells by Downregulating Cyclins and Cyclin-dependent KinasesSemantic proximity Read ↗

1,25-dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with function- and cell-specific additive effects.Semantic proximity Read ↗

Identification of receptor-selective retinoids that are potent inhibitors of the growth of human head and neck squamous cell carcinoma cells.Semantic proximity Read ↗

Retinoic acid receptor alpha drives cell cycle progression and is associated with increased sensitivity to retinoids in T-cell lymphoma.Semantic proximity Read ↗

RRIG1 Mediates Effects of Retinoic Acid Receptor β2 on Tumor Cell Growth and Gene Expression through Binding to and Inhibition of RhoASemantic proximity Read ↗

Combined Broccoli Sprouts and Green Tea Polyphenols Contribute to the Prevention of Estrogen Receptor-Negative Mammary Cancer via Cell Cycle Arrest and Inducing Apoptosis in HER2/neu Mice.Semantic proximity Read ↗

Recent Advances in Chemoprevention of CancerSemantic proximity Read ↗

Retinoblastoma gene-independent G1 phase arrest by flavone, phosphatidylinositol 3-kinase inhibitor, and histone deacetylase inhibitor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.