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Article

The Influence of 13- cis Retinoic Acid on Human Meibomian Gland Epithelial Cells

31 May 2013

Abstract excerpt

PURPOSE: Meibomian gland dysfunction (MGD) is a primary cause of dry eye disease. One of the risk factors for MGD is exposure to 13-cis retinoic acid (13-cis RA), a metabolite of vitamin A. However, the mechanism is not well understood. We hypothesize that 13-cis RA inhibits cell proliferation, promotes cell death, alters gene and protein expressions, and attenuates cell survival pathways in human meibomian gland...

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Identifiers

PMID: 23722388
DOI: 10.1167/iovs.13-11863

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