Article
Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 2008
Stern Joel N H, Keskin Derin B, Zhang Hong, Lv Huijuan, Kato Zenichiro, Strominger Jack L
Abstract excerpt
IL-10-secreting regulatory T cell lines specific to glatiramer acetate [poly(Y,E,A,K)n] or poly(Y,F,A,K)n have been established from the enlarged spleen and lymph nodes that result from copolymer treatment of SJL mice in which experimental autoimmune encephalomyelitis was induced by PLP139-151. These CD4+CD25+T cell lines secrete high levels of IL-10 and IL-13 but only small amounts of IL-4 and virtually no...
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