Article
Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific.
Cell reports - 13 Sept 2016
Tostanoski Lisa H, Chiu Yu-Chieh, Gammon Joshua M, Simon Thomas, Andorko James I, Bromberg Jonathan S, Jewell Christopher M
Abstract excerpt
Many experimental therapies for autoimmune diseases, such as multiple sclerosis (MS), aim to bias T cells toward tolerogenic phenotypes without broad suppression. However, the link between local signal integration in lymph nodes (LNs) and the specificity of systemic tolerance is not well understood. We used intra-LN injection of polymer particles to study tolerance as a function of signals in the LN...
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