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Article

Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry.

BMC cardiovascular disorders - 7 Mar 2011

Scheffold Thomas, Kullmann Silke, Huge Andreas, Binner Priska, Ochs Hermann R, Schöls Wolfgang, Thale Joachim, Motz Wolfgang, Hegge Franz Josef, Stellbrink Christoph, Dorsel Thomas, Gülker Hartmut, Heuer Hubertus, Dinh Wilfried, Stoll Monika, Haltern Georg

Abstract excerpt

BACKGROUND: Recent genome-wide association studies have identified several genetic loci linked to coronary artery disease (CAD) and myocardial infarction (MI). The 9p21.3 locus was verified by numerous replication studies to be the first common locus for CAD and MI. In the present study, we investigated whether six single nucleotide polymorphisms (SNP) rs1333049, rs1333040, rs10757274, rs2383206, rs10757278, and...

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Aged
Chromosomes, Human, Pair 9
Genetic Variation
Genome-Wide Association Study
Haplotypes
Myocardial Infarction
Registries
Young Adult

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Open in PubMed Open full text

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PMID: 21385355
DOI: 10.1186/1471-2261-11-9
PMCID: PMC3061953

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CAD

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