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Article

Single neuron ubiquitin-proteasome dynamics accompanying inclusion body formation in huntington disease.

The Journal of biological chemistry - 13 Feb 2009

Mitra Siddhartha, Tsvetkov Andrey S, Finkbeiner Steven

Abstract excerpt

The accumulation of mutant protein in intracellular aggregates is a common feature of neurodegenerative disease. In Huntington disease, mutant huntingtin leads to inclusion body (IB) formation and neuronal toxicity. Impairment of the ubiquitin-proteasome system (UPS) has been implicated in IB for...

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Identifiers

PMID: 19074152
DOI: 10.1074/jbc.M806269200
PMCID: PMC2640959

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19074152-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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