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Article

Evidence that proline focuses movement of the floppy loop of arylalkylamine N-acetyltransferase (EC 2.3.1.87).

The Journal of biological chemistry - 23 May 2008

Pavlicek Jiri, Coon Steven L, Ganguly Surajit, Weller Joan L, Hassan Sergio A, Sackett Dan L, Klein David C

Abstract excerpt

Arylalkylamine N-acetyltransferase (AANAT) catalyzes the N-acetylation of serotonin, the penultimate step in the synthesis of melatonin. Pineal AANAT activity increases at night in all vertebrates, resulting in increased melatonin production. This increases circulating levels of melatonin, thereby providing a hormonal signal of darkness. Kinetic and structural analysis of AANAT has determined that one element is...

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Identifiers

PMID: 18362150
DOI: 10.1074/jbc.M800593200
PMCID: PMC2386931

Genes

AANAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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