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Article

Enzyme adaptation to inhibitor binding: a cryptic binding site in phenylethanolamine N-methyltransferase.

Journal of medicinal chemistry - 4 Oct 2007

Gee Christine L, Drinkwater Nyssa, Tyndall Joel D A, Grunewald Gary L, Wu Qian, McLeish Michael J, Martin Jennifer L

Abstract excerpt

Shape complementarity is a fundamental principle of inhibitor design. Here we show that an enzyme for which the crystal structure has been determined (phenylethanolamine N-methyltransferase, PNMT) conceals a cryptic binding site. This site is revealed upon binding of inhibitors that are double the size of the physiological substrate. These large inhibitors are not predicted to bind in that they protrude through...

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Identifiers

PMID: 17845018
DOI: 10.1021/jm0703385

Genes

PNMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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