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Article

Enzyme adaptation to inhibitor binding: a cryptic binding site in phenylethanolamine N-methyltransferase.

Journal of medicinal chemistry - 4 Oct 2007

Gee Christine L, Drinkwater Nyssa, Tyndall Joel D A, Grunewald Gary L, Wu Qian, McLeish Michael J, Martin Jennifer L

Abstract excerpt

Shape complementarity is a fundamental principle of inhibitor design. Here we show that an enzyme for which the crystal structure has been determined (phenylethanolamine N-methyltransferase, PNMT) conceals a cryptic binding site. This site is revealed upon binding of inhibitors that are double th...

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Identifiers

PMID: 17845018
DOI: 10.1021/jm0703385

Genes

PNMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17845018-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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