Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanistic studies on the alkyltransferase activity of serotonin N-acetyltransferase.

Chemistry & biology - 1 Apr 2001

Zheng W, Scheibner K A, Ho A K, Cole P A

Abstract excerpt

BACKGROUND: Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) catalyzes the first, rate-limiting step in the biosynthesis of the circadian hormone melatonin (5-methoxy-N-acetyltryptamine) from serotonin. Our recent discovery that, in addition to catalyzing the acetyl trans...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkyl and Aryl Transferases
Share to Arylamine N-Acetyltransferase
Share to Catalysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrogen-Ion Concentration

Share to Inhibitory Concentration 50

Share to Melatonin

Share to Pineal Gland

Share to Serotonin

Source

Identifiers

PMID: 11325593
DOI: 10.1016/s1074-5521(01)00020-5

Genes

AANAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11325593-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanistic studies on the alkyltransferase activity of serotonin N-acetyltransferase.PMID 11325593Read ↗

Mechanism-based inhibition of the melatonin rhythm enzyme: pharmacologic exploitation of active site functional plasticity.Semantic proximity Read ↗

Structural and Molecular Dynamics Analysis of Plant Serotonin N-Acetyltransferase Reveal an Acid/Base-Assisted Catalysis in Melatonin Biosynthesis.Semantic proximity Read ↗

Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2.Semantic proximity Read ↗

An intramolecular disulfide bridge as a catalytic switch for serotonin N-acetyltransferase.Semantic proximity Read ↗

Evolution of arylalkylamine N-acetyltransferase: emergence and divergence.Semantic proximity Read ↗

Regulation of arylamine N-acetyltransferases.Semantic proximity Read ↗

Arylamine N-acetyltransferase.Semantic proximity Read ↗

[The biological role of prokaryotic and eukaryotic N-acetyltransferase].Semantic proximity Read ↗

The role of lysine(100) in the binding of acetylcoenzyme A to human arylamine N-acetyltransferase 1: implications for other acetyltransferases.Semantic proximity Read ↗

Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway.Semantic proximity Read ↗

Characterization of the Saccharomyces cerevisiae homolog of the melatonin rhythm enzyme arylalkylamine N-acetyltransferase (EC 2.3.1.87).Semantic proximity Read ↗

Molecular evolution of multiple arylalkylamine N-acetyltransferase (AANAT) in fish.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.