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Article

Structural and functional effects of nucleotide variation on the human TB drug metabolizing enzyme arylamine N-acetyltransferase 1.

Journal of molecular graphics & modelling - 1 Aug 2017

Cloete Ruben, Akurugu Wisdom A, Werely Cedric J, van Helden Paul D, Christoffels Alan

Abstract excerpt

The human arylamine N-acetyltransferase 1 (NAT1) enzyme plays a vital role in determining the duration of action of amine-containing drugs such as para-aminobenzoic acid (PABA) by influencing the balance between detoxification and metabolic activation of these drugs. Recently, four novel single nucleotide polymorphisms (SNPs) were identified within a South African mixed ancestry population. Modeling the effects...

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Source

Identifiers

PMID: 28628859
DOI: 10.1016/j.jmgm.2017.04.026

Genes

NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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