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Article

Structural basis of autoregulation of phenylalanine hydroxylase.

Nature structural biology - 1 May 1999

Kobe B, Jennings I G, House C M, Michell B J, Goodwill K E, Santarsiero B D, Stevens R C, Cotton R G, Kemp B E

Abstract excerpt

Phenylalanine hydroxylase converts phenylalanine to tyrosine, a rate-limiting step in phenylalanine catabolism and protein and neurotransmitter biosynthesis. It is tightly regulated by the substrates phenylalanine and tetrahydrobiopterin and by phosphorylation. We present the crystal structures of dephosphorylated and phosphorylated forms of a dimeric enzyme with catalytic and regulatory properties of the...

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PMID: 10331871
DOI: 10.1038/8247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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