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Article

Structural and Molecular Dynamics Analysis of Plant Serotonin N-Acetyltransferase Reveal an Acid/Base-Assisted Catalysis in Melatonin Biosynthesis.

Angewandte Chemie (International ed. in English) - 17 May 2021

Liao Lijing, Zhou Yuanze, Xu Youdong, Zhang Yuhao, Liu Xikai, Liu Biao, Chen Xinxin, Guo Yan, Zeng Zhixiong, Zhao Yucheng

Abstract excerpt

Serotonin N-acetyltransferase (SNAT) is the key rate-limiting enzyme in melatonin biosynthesis. It mediates melatonin biosynthesis in plants by using serotonin and 5-methoxytryptamine (5-MT), but little is known of its underlying mechanisms. Herein, we present a detailed reaction mechanism of a SNAT from Oryza sativa through combined structural and molecular dynamics (MD) analysis. We report the crystal...

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PMID: 33682300
DOI: 10.1002/anie.202100992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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