Article
Effects of nutrition and genotype on prion protein (PrPC) gene expression in the fetal and maternal sheep placenta.
Placenta - 1 May 2008
Evoniuk J M, Johnson M L, Borowicz P P, Caton J S, Vonnahme K A, Reynolds L P, Taylor J B, Stoltenow C L, O'Rourke K I, Redmer D A
Abstract excerpt
For placental transmission of scrapie to occur, the normal cellular prion protein (PrPC) must be converted to an abnormal infectious form known as PrPSc. PrPC genotype influences susceptibility to contracting scrapie, but we still do not understand whether genotype or expression levels of PrPC are important in transmission of scrapie. Some evidence exists that nutrition affects expression levels of PrPC. Thus, we...
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