Article
The incidence of genotypes at codon 171 of the prion protein gene (PRNP) in five breeds of sheep and production traits of ewes associated with those genotypes.
Journal of animal science - 1 Feb 2005
Alexander B M, Stobart R H, Russell W C, O'Rourke K I, Lewis G S, Logan J R, Duncan J V, Moss G E
Abstract excerpt
Scrapie is one of several transmissible spongiform encephalopathies of livestock. Disease susceptibility is linked to polymorphisms in the normal prion protein gene that encodes the mammalian prion precursor. Codon 171 of this gene is a major determinant of scrapie susceptibility. Selection for arginine (R) at codon 171 is encouraged by the USDA to decrease the incidence of scrapie. Objectives of this study were...
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