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Article

The discovery of novel human androgen receptor antagonist chemotypes using a combined pharmacophore screening procedure.

ChemMedChem - 1 Apr 2013

Voet Arnout, Helsen Christine, Zhang Kam Y J, Claessens Frank

Abstract excerpt

Unraveling the mechanisms involved in castration- and therapy-resistant prostate cancer has led to a renewed interest in androgen receptor (AR)-targeted therapeutics. Anti-androgens that block the activity of the AR therefore remain a valid therapeutic option. However, they must be more effective than, or display a distinct mechanism of action or binding mode from those of bicalutamide and hydroxyflutamide, which...

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Identifiers

PMID: 23436650
DOI: 10.1002/cmdc.201200549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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