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Article

Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.

Journal of the neurological sciences - 15 Jul 2008

Gaig Carles, Ezquerra Mario, Martí Maria José, Valldeoriola Francesc, Muñoz Esteban, Lladó Albert, Rey Maria Jesús, Cardozo Adriana, Molinuevo José Luis, Tolosa Eduardo

Abstract excerpt

BACKGROUND: The neuropathology associated with LRRK2 mutations is heterogeneous but Lewy body (LB) type pathology is the most common substrate encountered. While the prevalence of LRRK2 mutations has been extensively studied in Parkinson's disease (PD), limited information is available on the frequency of LRRK2 mutations in dementia with Lewy bodies (DLB) and in other pathological conditions associated with these...

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PMID: 18353371
DOI: 10.1016/j.jns.2008.02.010

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Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.PMID 18353371Read ↗

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The LRRK2 R1441C mutation is more frequent than G2019S in Parkinson's disease patients from southern Italy.Semantic proximity Read ↗

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LRRK2 G2019S mutation and Parkinson's disease: a clinical, neuropsychological and neuropsychiatric study in a large Italian sample.Semantic proximity Read ↗

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Mutations in LRRK2 other than G2019S are rare in a north American-based sample of familial Parkinson's disease.Semantic proximity Read ↗

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