Article
Screening for LRRK2 R1441 mutations in a cohort of PSP patients from Germany.
European journal of neurology - 1 Nov 2009
Madzar D, Schulte C, Gasser T
Abstract excerpt
BACKGROUND AND PURPOSE: Mutations in the leucine-rich repeat kinase gene (LRRK2) have been shown to be the most common genetic cause of both familial and sporadic Parkinson's disease. Patients harboring LRRK2 mutations develop late onset PD that in most cases cannot be clinically distinguished from idiopathic PD. Furthermore, LRRK2 mutations have been reported to result in a broad spectrum of neuropathological...
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