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Article

Exploring the active site cavity of human pancreatic lipase.

Biochemical and biophysical research communications - 6 Jun 2008

Colin Damien Yann, Deprez-Beauclair Paule, Allouche Maya, Brasseur Robert, Kerfelec Brigitte

Abstract excerpt

Within the scope of improving the efficiency of pancreatic enzyme replacement therapy in cystic fibrosis, the feasibility of shifting the pH-activity profile of pancreatic lipase toward acidic values was investigated by site specific mutagenesis in different regions of the catalytic cavity. We have shown that introducing a negative charge close to the catalytic histidine induced a shift of the pH optimum toward...

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Identifiers

PMID: 18353248
DOI: 10.1016/j.bbrc.2008.03.043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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