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Article

Redesigning protein pKa values.

Protein science : a publication of the Protein Society - 1 Feb 2007

Tynan-Connolly Barbara Mary, Nielsen Jens Erik

Abstract excerpt

The ability to re-engineer enzymatic pH-activity profiles is of importance for industrial applications of enzymes. We theoretically explore the feasibility of re-engineering enzymatic pH-activity profiles by changing active site pK(a) values using point mutations. We calculate the maximum achieva...

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PMID: 17189477
DOI: 10.1110/ps.062538707
PMCID: PMC2203286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17189477-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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