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Tailoring the pH dependence of human non-pancreatic secretory phospholipase A2 by engineering surface charges.

Applied biochemistry and biotechnology - 1 Nov 2013

Qiu Shunchen, Lai Luhua

Abstract excerpt

Human non-pancreatic secretory phospholipase A2 (hnpsPLA2) catalyzes the sn-2 acyl hydrolysis of phospholipids. It was reported that hnpsPLA2 is involved in various diseases like inflammation, cancer, and so on. This enzyme also exhibits anti-bacterial and anti-virus activities. It is active over a broad pH range, with higher activity at alkaline conditions. In order to make it suitable as a potential...

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PMID: 23955349
DOI: 10.1007/s12010-013-0437-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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