Article
Structure-function relationships of lipoprotein lipase: mutation analysis and mutagenesis of the loop region.
Journal of lipid research - 1 Sept 1993
Henderson H E, Ma Y, Liu M S, Clark-Lewis I, Maeder D L, Kastelein J J, Brunzell J D, Hayden M R
Abstract excerpt
The molecular models of two microbial lipases and human pancreatic lipase (PL) have suggested the existence of common structural motifs including a buried active site shielded by an amphipathic surface loop. In an effort to explore the role of residues comprising the loop of lipoprotein lipase (L...
Topics
- Base Sequence
- Cells, Cultured
- Computer Simulation
- DNA
- Humans
- Lipoprotein Lipase
- Models, Chemical
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Point Mutation
- Structure-Activity Relationship