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Article

Structure-function relationships of lipoprotein lipase: mutation analysis and mutagenesis of the loop region.

Journal of lipid research - 1 Sept 1993

Henderson H E, Ma Y, Liu M S, Clark-Lewis I, Maeder D L, Kastelein J J, Brunzell J D, Hayden M R

Abstract excerpt

The molecular models of two microbial lipases and human pancreatic lipase (PL) have suggested the existence of common structural motifs including a buried active site shielded by an amphipathic surface loop. In an effort to explore the role of residues comprising the loop of lipoprotein lipase (LPL), we have used site-directed mutagenesis to generate three new LPL variants. In variant LPLM1 we deleted 18 amino...

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Identifiers

PMID: 8228642

Genes

LPL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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