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Article

Pancreatic lipase structure-function relationships by domain exchange.

Biochemistry - 7 Jan 1997

Carrière F, Thirstrup K, Hjorth S, Ferrato F, Nielsen P F, Withers-Martinez C, Cambillau C, Boel E, Thim L, Verger R

Abstract excerpt

We designed chimeric mutants by exchanging the lid domains of the classical human pancreatic lipase (HPL) and the guinea pig pancreatic lipase related protein 2 (GPLRP2). This latter enzyme possesses naturally a large deletion within the lid domain and is not activated by lipid/water interfaces. Furthermore, GPLRP2 exhibits phospholipase A1 and lipase activities in the same order of magnitude, whereas HPL has no...

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Identifiers

PMID: 8993339
DOI: 10.1021/bi961991p

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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