Article
Up-regulation of MSX2 enhances the malignant phenotype and is associated with twist 1 expression in human pancreatic cancer cells.
The American journal of pathology - 1 Apr 2008
Satoh Kennichi, Hamada Shin, Kimura Kenji, Kanno Atsushi, Hirota Morihisa, Umino Jun, Fujibuchi Wataru, Masamune Atsushi, Tanaka Naoki, Miura Koh, Egawa Shinichi, Motoi Fuyuhiko, Unno Michiaki, Vonderhaar Barbara K, Shimosegawa Tooru
Abstract excerpt
MSX2 is thought to be a regulator of organ development and a downstream target of the ras signaling pathway; however, little is known about the role of MSX2 in the development of pancreatic cancers, most of which harbor a K-ras gene mutation. Therefore, we examined whether the presence of MSX2 correlates with the malignant behavior of pancreatic cancer cells. BxPC3 pancreatic cancer cells that stably overexpress...
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