Article

KMT2D links TGF-β Signalling to Non-Canonical Activin Pathway and Regulates Pancreatic Cancer Cell Plasticity

2020-04-03

Abstract excerpt

Although KMT2D, also known as MLL2, is known to play an essential role in development, differentiation, and tumor suppression, its role in pancreatic cancer development is not well understood. Here, we discovered a novel signaling axis mediated by KMT2D, which links TGF-β to the activin A pathway. We found that TGF-β upregulates a microRNA, miR-147b, which in turn leads to post-transcriptional silencing of KMT2D....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 213ab4d1-f602-5743-acef-4aaa991a14dc
DOI: 10.1101/2020.04.02.012138

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

KMT2D links TGF-β Signalling to Non-Canonical Activin Pathway and Regulates Pancreatic Cancer Cell PlasticityDOI 10.1101/2020.04.02.012138Read

<scp>KMT2D</scp> links <scp>TGF</scp> ‐β signaling to noncanonical activin pathway and regulates pancreatic cancer cell plasticitySemantic proximity Read

SMAD4 and the TGFβ Pathway in Patients with Pancreatic Ductal AdenocarcinomaSemantic proximity Read

MSI2 regulates NLK-mediated EMT and PI3K/AKT/mTOR pathway to promote pancreatic cancer progressionSemantic proximity Read

Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function.Semantic proximity Read

KMT2D mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-induced regulatory T cell trafficking via FBXW7-NOTCH-MYC/TGF-β1 axis.Semantic proximity Read

DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism.Semantic proximity Read

MAPKAPK2 (MK2) facilitates the epithelial-mesenchymal transition in lung adenocarcinoma through activation of the AKT/MYC signaling pathwaySemantic proximity Read

The TGF-β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancerSemantic proximity Read

MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3Semantic proximity Read

TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progressionSemantic proximity Read

Role for Daple in non‐canonical Wnt signaling during gastric cancer invasion and metastasisSemantic proximity Read

MEKK3 Sustains EMT and Stemness in Pancreatic Cancer by Regulating YAP and TAZ Transcriptional ActivitySemantic proximity Read