<scp>KMT2D</scp> links <scp>TGF</scp> ‐β signaling to noncanonical activin pathway and regulates pancreatic cancer cell plasticity

Abstract excerpt

Although KMT2D, also known as MLL2, is known to play an essential role in development, differentiation, and tumor suppression, its role in pancreatic cancer development is not well understood. Here, we discovered a novel signaling axis mediated by KMT2D, which links TGF-β to the activin A pathway. We found that TGF-β upregulates a microRNA, miR-147b, which in turn leads to post-transcriptional silencing of KMT2D....

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