Article
Opposite regulation of MDM2 and MDMX expression in acquisition of mesenchymal phenotype in benign and cancer cells.
Oncotarget - 3 Nov 2015
Slabáková Eva, Kharaishvili Gvantsa, Smějová Monika, Pernicová Zuzana, Suchánková Tereza, Remšík Ján, Lerch Stanislav, Straková Nicol, Bouchal Jan, Král Milan, Culig Zoran, Kozubík Alois, Souček Karel
Abstract excerpt
Plasticity of cancer cells, manifested by transitions between epithelial and mesenchymal phenotypes, represents a challenging issue in the treatment of neoplasias. Both epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are implicated in the processes of metastasis formation and acquisition of stem cell-like properties. Mouse double minute (MDM) 2 and MDMX are important players in...
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