Article
Decreased serum arylesterase activity in autism spectrum disorders.
Psychiatry research - 30 Dec 2010
Gaita Laura, Manzi Barbara, Sacco Roberto, Lintas Carla, Altieri Laura, Lombardi Federica, Pawlowski Tracy L, Redman Margot, Craig David W, Huentelman Matthew J, Ober-Reynolds Sharman, Brautigam Sarah, Melmed Raun, Smith Christopher J, Marsillach Judith, Camps Jordi, Curatolo Paolo, Persico Antonio M
Abstract excerpt
The PON1 gene, previously found associated with autism spectrum disorders (ASDs), encodes a serum protein responsible for the detoxification of organophosphates (OPs) and able to exert several enzymatic activities. PON1 arylesterase, but not diazoxonase activity, was significantly decreased in 174 ASD patients compared to 175 first-degree relatives and 144 controls (P=2.65×10⁻¹⁶). First degree relatives displayed...
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