Article
Functional paraoxonase 1 variants modify the risk of Parkinson's disease due to organophosphate exposure.
Environment international - 1 Jun 2013
Lee Pei-Chen, Rhodes Shannon L, Sinsheimer Janet S, Bronstein Jeff, Ritz Beate
Abstract excerpt
BACKGROUND: We previously demonstrated that carriers of the "slower metabolizer" MM genotype of paraoxonase (PON1) who were also exposed to ambient organophosphate (OP) pesticides at their residences were at increased risk of developing Parkinson's disease (PD). Here, with a larger sample size, we extend our previous investigation to consider additional sources of ambient exposure and examined two additional...
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