Article
Cervical carcinoma-associated fibroblasts are DNA diploid and do not show evidence for somatic genetic alterations.
Cellular oncology (Dordrecht, Netherlands) - 1 Dec 2011
Corver Willem Ernst, Ter Haar Natalja Tatjana, Fleuren Gert Jan, Oosting Jan
Abstract excerpt
BACKGROUND: Cancer-associated fibroblasts (CAFs) have been recognized as important contributors to cancer development and progression. However, opposing evidence has been published whether CAFs, in addition to epigenetic, also undergo somatic genetic alterations and whether these changes contribute to carcinogenesis and tumour progression. METHODS: We combined multiparameter DNA flow cytometry, flow-sorting and...
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