Article
A robust linkage analysis method using combined allele sharing and transmission disequilibrium information from case-parent tetrad families.
Annals of human genetics - 1 Jul 2008
Wang J-Y, Hou C-D, Tai J J
Abstract excerpt
There are two types of linkage information, the allele sharing information and transmission disequilibrium information, that can be extracted from case-parent tetrad families for deriving statistics for test of linkage. By extracting allele sharing information the mean test can be derived. By extracting transmission disequilibrium information the transmission/disequilibrium test (TDT) can be derived. The power...
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