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Article

Probing the acyl-binding pocket of aminoacylase-1.

Biochemistry - 8 Apr 2008

Lindner Holger A, Alary Alain, Wilke Marsha, Sulea Traian

Abstract excerpt

The aminoacylase-1/metallopeptidase 20 (Acy1/M20) family features several l-aminoacylases useful in biocatalysis. Mammalian Acy1, in particular, has been applied in racemic resolution and reverse hydrolysis. Despite recent advances in our understanding of the active site architecture and functioning, determinants of Acy1 substrate specificity have remained uncharted. Comparison to bacterial homologues points to a...

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PMID: 18341290
DOI: 10.1021/bi702156h

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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