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Article

Roles of dimerization domain residues in binding and catalysis by aminoacylase-1.

Biochemistry - 6 Dec 2005

Lindner Holger A, Alary Alain, Boju Lorena I, Sulea Traian, Ménard Robert

Abstract excerpt

The aminoacylase-1/metallopeptidase 20 (Acy1/M20) family is the largest metallopeptidase family. Several crystal structures feature a metal-binding and a dimerization-mediating domain, both arranged in an extended open conformation. We have recently shown [Lindner et al. (2003) J. Biol. Chem. 278, 44496-44504] that in human Acy1 the invariant residues Glu147 and His206 from the metal-binding and the dimerization...

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PMID: 16313167
DOI: 10.1021/bi051180y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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