Article
PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations.
Cancer research - 15 Mar 2008
Li Yunqing, Guessous Fadila, Kwon Sherwin, Kumar Manish, Ibidapo Opeyemi, Fuller Lauren, Johnson Elizabeth, Lal Bachchu, Hussaini Isa, Bao Yongde, Laterra John, Schiff David, Abounader Roger
Abstract excerpt
We show, for the first time, that the tumor suppressor PTEN can have tumor-promoting properties. We show that PTEN acquires these unexpected properties by enhancing gain-of-function mutant p53 (mut-p53) protein levels. We find that PTEN restoration to cells harboring mut-p53 leads to induction of G(1)-S cell cycle progression and cell proliferation and to inhibition of cell death. Conversely, PTEN inhibition in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.