Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy.

Neoplasia (New York, N.Y.) - 1 Aug 2013

Huang Xiaoping, Zhang Ying, Tang Yaqiong, Butler Napoleon, Kim Jungeun, Guessous Fadila, Schiff David, Mandell James, Abounader Roger

Abstract excerpt

Phosphatase and tensin homolog located on chromosome 10 (PTEN) is one of the most frequently mutated tumor suppressors in human cancer including in glioblastoma. Here, we show that PTEN exerts unconventional oncogenic effects in glioblastoma through a novel PTEN/mutant p53/c-Myc/Bcl-XL molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-X Protein
Share to CCAAT-Binding Factor
Share to Chromatin Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioblastoma

Share to Immunoblotting

Share to Proto-Oncogene Proteins c-myc

Share to PTEN Phosphohydrolase

Share to Sialoglycoproteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23908595
DOI: 10.1593/neo.13376
PMCID: PMC3730046

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23908595-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy.PMID 23908595Read ↗

Combined PTEN Mutation and Protein Expression Associate with Overall and Disease-Free Survival of Glioblastoma PatientsSemantic proximity Read ↗

PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations.Semantic proximity Read ↗

PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy.Semantic proximity Read ↗

Decoding PTEN: from biological functions to signaling pathways in tumors.Semantic proximity Read ↗

Revising PTEN in the Era of Immunotherapy: New Perspectives for an Old StorySemantic proximity Read ↗

PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastomaSemantic proximity Read ↗

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.Semantic proximity Read ↗

The PTEN tumor suppressor gene and its role in lymphoma pathogenesis.Semantic proximity Read ↗

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis.Semantic proximity Read ↗

The Novel Phosphatase Domain Mutations Q171R and Y65S Switch PTEN from Tumor Suppressor to Oncogene.Semantic proximity Read ↗

Tenets of PTEN tumor suppression.Semantic proximity Read ↗

Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.