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Article

Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene.

Molecular and cellular biology - 1 Oct 1991

Decker T, Lew D J, Darnell J E

Abstract excerpt

The promoter of the gene encoding a cytoplasmic guanylate-binding protein (GBP) contains two overlapping elements: the interferon stimulation response element (ISRE), which mediates alpha interferon (IFN-alpha)-dependent transcription, and the IFN-gamma activation site (GAS), which is required for IFN-gamma-mediated stimulation. The ISRE binds a factor called ISGF-3 that is activated by IFN-alpha but not by...

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Identifiers

PMID: 1833631
DOI: 10.1128/mcb.11.10.5147-5153.1991
PMCID: PMC361534

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