Article
Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene.
Molecular and cellular biology - 1 Oct 1991
Decker T, Lew D J, Darnell J E
Abstract excerpt
The promoter of the gene encoding a cytoplasmic guanylate-binding protein (GBP) contains two overlapping elements: the interferon stimulation response element (ISRE), which mediates alpha interferon (IFN-alpha)-dependent transcription, and the IFN-gamma activation site (GAS), which is required fo...
Topics
- Base Sequence
- Cell Line
- GTP-Binding Proteins
- HeLa Cells
- Humans
- Interferon Type I
- Interferon-gamma
- Kinetics
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Receptors, Immunologic
- Receptors, Interferon
- Recombinant Proteins
- Signal Transduction
- Transcription Factors
- Transcription, Genetic